BACKGROUND: Although the human genome database has been completed a decade ago, approximately 50% of the proteome remains hypothetical as their functions are unknown.The elucidation of the functions of these hypothetical proteins can lead to additional protein pathways and revelation of new cascades.However, many of these inferences are limited to
Intellectual property rights (IPR), and patents in particular, play a central role the commercialisation of new knowledge and Laboratory techniques in the life sciences.This paper analyses the effects of the patent ecosystem using the sociology of valuation and evaluation.Specifically, the patent ecosystem can be interrogated in terms of which acti
Crambescins are guanidine alkaloids from the sponge Crambe crambe.Crambescin C1 (CC) induces metallothionein genes and nitric oxide (NO) is one of the triggers.We studied and compared the in vitro, in vivo, and in silico effects of some crambescine A and C analogs.HepG2 gene expression was analyzed using microarrays.Vasodilation was studied in rat
Introduction: Dural arteriovenous fistulas are abnormal communications between the arterial and dural sinus vessels or the cortical veins.Multiple dural arteriovenous fistulae have an incidence rate of 6-9%.Their pathophysiology is poorly understood, although there is a consensus on three theories for their formation.The systemic infection caused b